modafinil will lessen the extent or influence of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
tecovirimat will boost the stage or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. Tecovirimat is usually a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse effects if coadministered with sensitive substrates of such enzymes.
nelfinavir will enhance the stage or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Folks have documented blacking out soon after only minimal quantities of Alcoholic beverages though taking modafinil, plus some Individuals who have only taken one dose of Adderall blended with one consume have ended up in clinic.
primidone will reduce the extent or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
mitotane decreases levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Mitotane is a strong inducer of cytochrome P-4503A4; observe when coadministered with CYP3A4 substrates for attainable dosage adjustments.
modafinil will lower the level or influence of mavacamten by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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Pediatric Use: Performance and protection in pediatric sufferers are certainly not established. Modafinil isn't FDA-authorised for use within the pediatric populace for almost any sign.
acetazolamide will increase the amount or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.
The purpose of this critique is always to introduce realistic application of modafinil being an alertness-maximizing and anti-tiredness drug, and to discuss pharmacological and immunomodulatory effects of modafinil, of which the very first effect is harmless, even perfect.
Coadministration of encorafenib with sensitive CYP3A4 substrates may well result in improved toxicity or diminished efficacy of such agents.
Modafinil may reduce serum concentrations of other medication into a clinically substantial extent, including the following:
They concluded which the cortical effects of modafinil are the results of reduced GABA transmission while in the cortex.